CPE

Across TCGA patient cohorts, CPE mutation is significantly associated with the RNA expression of many other genes, with 2,857 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPE-associated genes across cancer lineages are ADAM33, CCT5, and HAUS1. Each is linked with CPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CPE-to-partner and partner-to-CPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM33 grouped by CPE-low versus CPE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPE→partner) and Y-score (partner→CPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAM33 →	-0.757	-1.915	.008	.005	3	2
UCEC	CCT5 →	+0.516	+2.754	.005	.002	3	2
UCEC	HAUS1 →	+0.656	+3.828	<.001	<.001	3	2
UCEC	SUPV3L1 →	+0.367	+2.332	.003	<.001	3	2
UCEC	TATDN2 →	+0.440	+3.480	<.001	<.001	3	2
UCEC	NTAN1 →	+0.467	+2.375	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,857 associations by consensus.

ADAM33 by CPE expression — UCEC

Explore this box plot interactively →