CPE

Across TCGA pan-cancer cohorts, CPE RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CPE data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CPE RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CPE expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

BLCA, UVM, and CESC are the cancer types where CPE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.268	0.550	<.001	144	view →
UVM	DFS	Median	II,III,IV	0.562	0.880	<.001	130	view →
CESC	OS	Median	II,III,IV	0.370	0.812	<.001	90	view →
LGG	OS	Median	All	0.942	0.851	<.001	43	view →
STAD	OS	Tertile	All	0.472	0.663	.011	29	view →
KIRC	DFS	Median	III,IV	0.789	0.693	.015	27	view →
UCEC	DFS	Quartile	All	0.792	0.894	.004	24	view →
PAAD	DFS	Tertile	All	0.419	0.201	.009	19	view →
THCA	DFS	Quartile	All	0.880	0.745	.016	13	view →
ACC	OS	Quartile	II,III,IV	0.640	1.000	.018	12	view →
ESCA	OS	Median	All	1.000	0.693	.038	12	view →
HNSC	DFS	Quartile	IV	0.759	0.570	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CPE–BLCA (OS)

Open the BLCA breakdown →