CPE

Across TCGA patient cohorts, CPE mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPE-associated genes across cancer lineages are INPP4B, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with CPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CPE-to-partner and partner-to-CPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CPE-low versus CPE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPE→partner) and Y-score (partner→CPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.375	-3.700	.005	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.385	-1.794	.038	.027	3	2
SKCM	PDCD4 →	-0.664	-3.000	<.001	.034	3	2
UCEC	ASNS →	+0.526	+2.584	<.001	.010	3	2
UCEC	ATM →	-0.668	-3.321	<.001	.010	3	2
SKCM	14-3-3_epsilon →	+0.176	+3.321	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

INPP4B by CPE expression — UCEC

Explore this box plot interactively →