CPE

Across TCGA cell cohorts, CPE mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CPE-associated genes across cancer lineages are LCE6A, ST8SIA3, and KCNK4. Each is linked with CPE in more than 1 cancer types. Because this analysis shows association rather than direction, both CPE-to-partner and partner-to-CPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE6A grouped by CPE-low versus CPE-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPE→partner) and Y-score (partner→CPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LCE6A →	+0.397	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ST8SIA3 →	+0.023	+2.657	.004	.007	3	1
LARGE_INTESTINE	KCNK4 →	+0.047	+3.708	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4K2 →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR2M4 →	+0.121	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR2T4 →	+0.030	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LCE6A by CPE expression — SKIN

Explore this box plot interactively →