CPAMD8

Across TCGA patient cohorts, CPAMD8 mutation is significantly associated with the RNA expression of many other genes, with 7,078 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPAMD8-associated genes across cancer lineages are EXO1, DEPDC1, and NCAPG. Each is linked with CPAMD8 in more than 5 cancer types. Because this analysis shows association rather than direction, both CPAMD8-to-partner and partner-to-CPAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXO1 grouped by CPAMD8-low versus CPAMD8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPAMD8→partner) and Y-score (partner→CPAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EXO1 →	+1.123	+3.611	<.001	.001	3	6
UCEC	DEPDC1 →	+0.484	+1.496	<.001	<.001	3	6
UCEC	NCAPG →	+0.679	+2.765	<.001	<.001	3	5
LUAD	KIF11 →	+0.863	+3.477	.002	.002	3	5
STAD	WRAP53 →	+0.440	+3.000	<.001	<.001	3	5
STAD	TXNL4A →	+0.355	+3.359	.006	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,078 associations by consensus.

EXO1 by CPAMD8 expression — LUAD

Explore this box plot interactively →