CPAMD8

Across TCGA pan-cancer cohorts, CPAMD8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CPAMD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CPAMD8 RNA is repressed in tumor relative to normal tissue. In most cancer types CPAMD8 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where CPAMD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPAMD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.658	<.001	12	view →
KICH	All	IV	−3.772	<.001	11	view →
LUAD	Male	III,IV	−3.243	<.001	11	view →
KIRP	Male	III,IV	−2.812	<.001	11	view →
COAD	Female	II,III,IV	−0.643	<.001	10	view →
BRCA	All	III,IV	−1.711	<.001	8	view →
LUSC	Female	II,III,IV	−3.655	<.001	6	view →
CHOL	All	All	+0.684	.003	3	view →
PRAD	All	All	−1.129	<.001	2	view →
HNSC	All	IV	−0.538	.038	2	view →
STAD	Male	IV	−0.510	.048	1	view →
LIHC	Male	All	−0.129	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CPAMD8–KIRC

Open the KIRC breakdown →