CPAMD8

Across TCGA cell cohorts, CPAMD8 mutation is significantly associated with the RNA expression of many other genes, with 1,819 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPAMD8-associated genes across cancer lineages are HINT3, SKA1, and HMGN4. Each is linked with CPAMD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPAMD8-to-partner and partner-to-CPAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINT3 grouped by CPAMD8-low versus CPAMD8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPAMD8→partner) and Y-score (partner→CPAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HINT3 →	+0.562	+3.459	.003	.001	3	3
LARGE_INTESTINE	SKA1 →	+0.832	+3.043	<.001	<.001	3	3
LARGE_INTESTINE	HMGN4 →	+0.542	+2.364	<.001	<.001	3	3
BLOOD_Leukemia	ASPHD2 →	+0.744	+3.489	.002	.001	3	3
BLOOD_Leukemia	RPL15 →	+0.447	+3.489	<.001	.001	3	3
BLOOD_Leukemia	METTL6 →	+0.423	+3.489	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,819 associations by consensus.

HINT3 by CPAMD8 expression — LARGE_INTESTINE

Explore this box plot interactively →