CPA6

Across TCGA patient cohorts, CPA6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPA6-associated genes across cancer lineages are Notch1, 14-3-3_beta, and Fibronectin. Each is linked with CPA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA6-to-partner and partner-to-CPA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CPA6-low versus CPA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA6→partner) and Y-score (partner→CPA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.107	+2.335	.048	.018	3	2
UCEC	14-3-3_beta →	-0.084	-1.664	.029	.023	3	1
UCEC	Fibronectin →	-0.353	-3.797	.005	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.630	+2.584	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.133	-2.459	.039	.019	3	1
UCEC	LKB1 →	-0.100	-2.584	.014	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by CPA6 expression — UCEC

Explore this box plot interactively →