CPA6

Across TCGA pan-cancer cohorts, CPA6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CPA6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CPA6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CPA6 is over-expressed in tumor, although a few such as COAD and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where CPA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.505	<.001	12	view →
KIRC	Female	All	+0.691	<.001	12	view →
LIHC	All	All	+0.333	.002	6	view →
THCA	Female	III,IV	+0.083	.006	6	view →
BRCA	All	II,III,IV	+0.623	.002	4	view →
LUSC	Female	All	+1.383	.002	3	view →
KICH	All	All	+0.823	.009	3	view →
COAD	All	II,III,IV	−0.675	.014	3	view →
PAAD	Female	All	+1.495	.020	2	view →
PRAD	All	All	−1.404	<.001	2	view →
LUAD	All	IV	+0.255	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CPA6–HNSC

Open the HNSC breakdown →