CPA4

Across TCGA cell cohorts, CPA4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPA4-associated genes across cancer lineages are NAA11, MMP26, and OR2C1. Each is linked with CPA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA4-to-partner and partner-to-CPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA11 grouped by CPA4-low versus CPA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA4→partner) and Y-score (partner→CPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA11 →	+0.419	+3.472	<.001	.005	3	1
LARGE_INTESTINE	MMP26 →	+0.035	+4.047	<.001	<.001	3	1
LARGE_INTESTINE	OR2C1 →	+0.084	+3.426	.007	.007	3	1
LARGE_INTESTINE	PPDPFL →	+0.034	+3.217	<.001	.006	3	1
LARGE_INTESTINE	CYP4Z1 →	+0.313	+3.472	<.001	.005	3	1
LARGE_INTESTINE	OR2J1 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NAA11 by CPA4 expression — LARGE_INTESTINE

Explore this box plot interactively →