CPA2

Across TCGA patient cohorts, CPA2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPA2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Chk2. Each is linked with CPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA2-to-partner and partner-to-CPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CPA2-low versus CPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA2→partner) and Y-score (partner→CPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.771	+2.827	.017	.035	3	2
UCEC	PCNA →	+0.251	+3.169	.034	.020	2	1
UCEC	Chk2 →	-0.254	-3.169	.048	.020	2	1
UCEC	ER-alpha_pS118 →	-0.410	-3.169	.037	.020	1	1
UCEC	Notch1 →	+0.296	+3.169	<.001	.020	1	1
UCEC	p62 Lck ligand →	+0.562	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by CPA2 expression — UCEC

Explore this box plot interactively →