CPA2

Across TCGA pan-cancer cohorts, CPA2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CPA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CPA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CPA2 is over-expressed in tumor, although a few such as STAD and BRCA show the opposite, repressed pattern.

HNSC, STAD, and BRCA are the cancer types where CPA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.240	<.001	9	view →
STAD	All	IV	−5.299	.002	7	view →
BRCA	All	III,IV	−0.640	<.001	6	view →
COAD	All	II,III,IV	−0.647	<.001	4	view →
THCA	Male	II,III,IV	−0.138	<.001	4	view →
LUSC	Male	All	+0.380	<.001	3	view →
LUAD	Female	II,III,IV	−0.099	.021	3	view →
PRAD	All	All	−0.111	<.001	2	view →
ESCA	All	All	−3.979	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CPA2–HNSC

Open the HNSC breakdown →