CPA1

Across TCGA patient cohorts, CPA1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPA1-associated genes across cancer lineages are INPP4B, 14-3-3_beta, and Heregulin. Each is linked with CPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA1-to-partner and partner-to-CPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CPA1-low versus CPA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA1→partner) and Y-score (partner→CPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.350	-3.313	.046	.010	3	1
UCEC	14-3-3_beta →	-0.110	-2.432	.004	.018	3	1
UCEC	Heregulin →	-0.110	-1.861	.020	.049	3	1
UCEC	p62 Lck ligand →	+0.354	+2.087	.004	.005	3	1
UCEC	Smad3 →	-0.166	-1.678	.004	.023	3	1
UCEC	Caspase-7-cleavedD198 →	+0.500	+2.604	.028	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

INPP4B by CPA1 expression — COAD

Explore this box plot interactively →