CPA1

Across TCGA pan-cancer cohorts, CPA1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CPA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CPA1 RNA is repressed in tumor relative to normal tissue. In most cancer types CPA1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LUAD are the cancer types where CPA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.649	<.001	11	view →
KIRC	Male	All	−0.421	<.001	10	view →
LUAD	Female	All	−0.200	<.001	8	view →
KICH	Female	All	−0.490	<.001	7	view →
BRCA	All	All	−1.418	<.001	6	view →
UCEC	All	All	−0.426	<.001	6	view →
LUSC	Male	III,IV	−0.110	<.001	4	view →
PRAD	All	All	−0.270	<.001	2	view →
STAD	Male	All	−0.427	.013	1	view →
COAD	All	IV	−0.042	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CPA1–KIRP

Open the KIRP breakdown →