CPA1

Across TCGA cell cohorts, CPA1 mutation is significantly associated with the RNA expression of many other genes, with 185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPA1-associated genes across cancer lineages are ADAM30, GLRA4, and CCL18. Each is linked with CPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPA1-to-partner and partner-to-CPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM30 grouped by CPA1-low versus CPA1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPA1→partner) and Y-score (partner→CPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM30 →	+0.011	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	GLRA4 →	+0.193	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	CCL18 →	+0.037	+4.212	<.001	.007	3	1
LARGE_INTESTINE	DNAL4 →	+0.570	+3.169	.001	.009	3	1
LARGE_INTESTINE	PMM1 →	+0.656	+3.169	.001	.009	3	1
LARGE_INTESTINE	VAPA →	+0.538	+3.169	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 185 associations by consensus.

ADAM30 by CPA1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →