COX7C

Across TCGA pan-cancer cohorts, COX7C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated COX7C data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher COX7C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COX7C expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

UCS, MESO, and LUAD are the cancer types where COX7C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.285	0.610	.004	84	view →
MESO	OS	Tertile	II,III,IV	0.556	0.312	.001	82	view →
LUAD	OS	Tertile	III,IV	0.273	0.711	.001	50	view →
UVM	DFS	Tertile	III,IV	0.337	0.929	.005	46	view →
STAD	OS	Quartile	All	0.444	0.702	.004	46	view →
SCLC	OS	Median	All	0.312	0.623	<.001	40	view →
KICH	DFS	Quartile	II,III,IV	0.499	1.000	.002	35	view →
LIHC	OS	Median	III,IV	0.354	0.687	.001	25	view →
ESCA	DFS	Quartile	All	0.383	0.651	.003	23	view →
KIRC	OS	Quartile	All	0.726	0.547	.004	21	view →
COAD	OS	Quartile	III,IV	0.959	0.673	.004	20	view →
THCA	DFS	Tertile	All	0.976	0.902	.013	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

COX7C–UCS (DFS)

Open the UCS breakdown →