COX7C

Across TCGA pan-cancer cohorts, COX7C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of COX7C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COX7C RNA is repressed in tumor relative to normal tissue. In most cancer types COX7C is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where COX7C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX7C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.466	<.001	10	view →
HNSC	Male	All	−0.495	<.001	9	view →
LIHC	Female	II,III,IV	+0.895	<.001	7	view →
STAD	Male	All	−0.553	<.001	5	view →
BLCA	All	IV	−0.461	.003	5	view →
KIRC	Female	IV	+0.543	.003	4	view →
BRCA	All	III,IV	+0.413	<.001	4	view →
CHOL	All	All	+1.107	<.001	3	view →
READ	All	All	−0.677	.009	2	view →
KICH	Male	All	+0.439	.043	2	view →
LUSC	All	All	−0.196	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

COX7C–COAD

Open the COAD breakdown →