COX7C

Across TCGA pan-cancer cohorts, COX7C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COX7C data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COX7C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COX7C expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where COX7C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.936	0.657	.002	31	view →
CCRCC	OS	Median	II,III,IV	1.000	0.373	.006	23	view →
GBM	DFS	Median	All	0.813	0.626	<.001	8	view →
PDAC	DFS	Tertile	III,IV	0.519	0.954	.014	6	view →
LUAD	OS	Median	All	0.623	0.867	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COX7C–LSCC (OS)

Open the LSCC breakdown →