COX7C

Across TCGA pan-cancer cohorts, COX7C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of COX7C’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where COX7C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types COX7C is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where COX7C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX7C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−1.586	<.001	12	view →
HNSC	Female	All	−0.730	<.001	12	view →
LUAD	Female	II,III,IV	+0.589	<.001	9	view →
PDAC	Male	All	−1.183	<.001	6	view →
LSCC	Male	All	+0.341	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

COX7C–CCRCC

Open the CCRCC breakdown →