COX5B

Across TCGA pan-cancer cohorts, COX5B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COX5B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COX5B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COX5B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where COX5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.832	0.442	.002	70	view →
LSCC	OS	Median	All	0.916	0.713	.001	50	view →
PDAC	OS	Tertile	All	0.974	0.694	.012	20	view →
OV	DFS	Tertile	All	0.923	0.517	.043	16	view →
COAD	DFS	Median	II,III,IV	1.000	0.880	.019	12	view →
HNSC	DFS	Quartile	All	0.643	0.900	.012	5	view →
GBM	OS	Quartile	All	0.893	0.714	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COX5B–CCRCC (OS)

Open the CCRCC breakdown →