COX5A

Across TCGA patient cohorts, COX5A mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX5A-associated genes across cancer lineages are RNU6-1213P, CT45A3, and FAM25G. Each is linked with COX5A in more than 1 cancer types. Because this analysis shows association rather than direction, both COX5A-to-partner and partner-to-COX5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by COX5A-low versus COX5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX5A→partner) and Y-score (partner→COX5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1213P →	+0.344	+4.292	<.001	.006	3	2
UCEC	CT45A3 →	+0.188	+2.914	.007	.008	3	2
COAD	FAM25G →	+0.180	+5.790	<.001	.003	3	1
COAD	RNU6-1309P →	+0.436	+5.357	.001	.006	3	1
COAD	RNU6-1319P →	+0.472	+6.122	<.001	.002	3	1
COAD	OR2W2P →	+0.120	+6.122	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

RNU6-1213P by COX5A expression — UCEC

Explore this box plot interactively →