COX4I2

Across TCGA patient cohorts, COX4I2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX4I2-associated genes across cancer lineages are FOXO3a_pS318_S321, Stathmin, and PDCD4. Each is linked with COX4I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX4I2-to-partner and partner-to-COX4I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by COX4I2-low versus COX4I2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX4I2→partner) and Y-score (partner→COX4I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.164	-3.000	.023	.037	3	1
UCEC	Stathmin →	+0.191	+3.000	.016	.037	3	1
UCEC	PDCD4 →	-0.668	-3.000	.014	.037	2	1
UCEC	eIF4E →	+0.246	+3.000	.044	.037	1	1
UCEC	mTOR_pS2448 →	-0.220	-3.000	.010	.037	1	1
UCEC	Shc_pY317 →	-0.231	-3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FOXO3a_pS318_S321 by COX4I2 expression — UCEC

Explore this box plot interactively →