COX4I2

Across TCGA pan-cancer cohorts, COX4I2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated COX4I2 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COX4I2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COX4I2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

UVM, KIRP, and BLCA are the cancer types where COX4I2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.340	0.824	<.001	86	view →
KIRP	OS	Tertile	All	0.494	0.796	<.001	60	view →
BLCA	OS	Tertile	IV	0.155	0.490	<.001	59	view →
COAD	DFS	Median	III,IV	0.585	0.747	.007	58	view →
LUSC	DFS	Tertile	All	0.543	0.744	<.001	38	view →
HNSC	DFS	Quartile	II,III,IV	0.431	0.179	.007	35	view →
ACC	OS	Median	IV	0.287	0.799	.006	29	view →
UCS	DFS	Tertile	IV	0.321	0.953	.024	24	view →
MESO	DFS	Quartile	II,III,IV	0.671	0.138	.006	24	view →
UCEC	DFS	Tertile	All	0.845	0.937	<.001	24	view →
LAML	DFS	Median	All	0.546	0.369	.009	24	view →
THCA	DFS	Median	All	0.880	0.774	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

COX4I2–UVM (OS)

Open the UVM breakdown →