COX4I2

Across TCGA cell cohorts, COX4I2 mutation is significantly associated with the mutation status of many other genes, with 1,124 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COX4I2-associated genes across cancer lineages are MEIS2, CCT7, and GPR87. Each is linked with COX4I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX4I2-to-partner and partner-to-COX4I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEIS2 grouped by COX4I2-low versus COX4I2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX4I2→partner) and Y-score (partner→COX4I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MEIS2 →	+6.321	+6.321	.001	.001	1	2
SKIN	CCT7 →	+4.824	+5.392	.004	.004	1	2
SKIN	GPR87 →	+5.824	+5.824	.002	.002	1	2
BLOOD_Leukemia	TMOD3 →	+5.321	+5.894	.002	.002	1	2
SKIN	ZYX →	+5.824	+5.824	.002	.002	1	2
SKIN	MLST8 →	+4.824	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,124 associations by consensus.

MEIS2 by COX4I2 expression — BLOOD_Leukemia

Explore this box plot interactively →