COX4I1

Across TCGA patient cohorts, COX4I1 mutation is significantly associated with the RNA expression of many other genes, with 226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX4I1-associated genes across cancer lineages are EIF3JP1, LINC02559, and VN1R93P. Each is linked with COX4I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX4I1-to-partner and partner-to-COX4I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3JP1 grouped by COX4I1-low versus COX4I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX4I1→partner) and Y-score (partner→COX4I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3JP1 →	+0.214	+2.883	<.001	<.001	3	2
SKCM	LINC02559 →	+0.263	+6.624	<.001	.001	3	2
SKCM	VN1R93P →	+0.096	+5.292	<.001	.006	3	1
SKCM	RNU6-1169P →	+0.425	+5.362	<.001	.005	3	1
SKCM	RN7SKP206 →	+0.168	+5.362	.001	.005	3	1
SKCM	YY1P2 →	+0.059	+6.993	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 226 associations by consensus.

EIF3JP1 by COX4I1 expression — UCEC

Explore this box plot interactively →