COX19

Across TCGA patient cohorts, COX19 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX19-associated genes across cancer lineages are MIR4306, MIR3927, and IL21. Each is linked with COX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX19-to-partner and partner-to-COX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4306 grouped by COX19-low versus COX19-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX19→partner) and Y-score (partner→COX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4306 →	+0.626	+5.822	<.001	.003	3	1
HNSC	MIR3927 →	+1.474	+6.936	<.001	<.001	3	1
UCEC	IL21 →	+0.213	+4.348	.001	.001	3	1
LUSC	RNU4-67P →	+0.174	+7.924	<.001	.008	3	1
LUSC	MIR1302-7 →	+0.288	+7.924	<.001	.008	3	1
LUSC	SNRPFP3 →	+1.066	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MIR4306 by COX19 expression — HNSC

Explore this box plot interactively →