COX19

Across TCGA pan-cancer cohorts, COX19 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COX19’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COX19 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COX19 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where COX19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.868	<.001	11	view →
KIRC	Male	IV	+0.696	<.001	11	view →
COAD	Male	IV	+0.885	<.001	10	view →
LIHC	Female	II,III,IV	+1.225	<.001	9	view →
STAD	Male	II,III,IV	+1.127	<.001	9	view →
BLCA	All	All	+0.666	<.001	8	view →
KIRP	All	All	+0.412	.003	8	view →
THCA	All	All	−0.259	<.001	7	view →
LUAD	Male	II,III,IV	+0.473	.008	6	view →
CHOL	Male	All	+2.386	<.001	5	view →
LUSC	Male	All	+0.665	<.001	4	view →
READ	Female	All	+1.158	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COX19–HNSC

Open the HNSC breakdown →