COX11

Across TCGA pan-cancer cohorts, COX11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COX11 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher COX11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COX11 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where COX11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.499	0.979	.020	18	view →
PDAC	OS	Tertile	III,IV	0.165	0.934	.003	16	view →
CCRCC	OS	Quartile	II,III,IV	0.674	0.986	.025	4	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.876	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COX11–HNSC (OS)

Open the HNSC breakdown →