COX11

Across TCGA pan-cancer cohorts, COX11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of COX11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where COX11 RNA is repressed in tumor relative to normal tissue. In most cancer types COX11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where COX11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.488	<.001	9	view →
KICH	Female	II,III,IV	−1.902	<.001	8	view →
LIHC	Male	All	+0.679	<.001	8	view →
KIRC	All	All	−0.217	<.001	7	view →
CHOL	All	All	+1.095	<.001	5	view →
LUAD	All	All	+0.245	<.001	4	view →
HNSC	All	III,IV	+0.352	.024	3	view →
LUSC	All	III,IV	−0.488	.001	2	view →
STAD	All	II,III,IV	+0.410	.016	2	view →
COAD	Female	IV	−0.675	.019	1	view →
ESCA	All	All	+0.580	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

COX11–THCA

Open the THCA breakdown →