COX11

Across TCGA patient cohorts, COX11 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX11-associated genes across cancer lineages are A-Raf_pS299, Fibronectin, and Heregulin. Each is linked with COX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX11-to-partner and partner-to-COX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by COX11-low versus COX11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX11→partner) and Y-score (partner→COX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.164	-2.321	.002	.034	3	1
UCEC	Fibronectin →	-0.301	-2.000	.042	.032	3	1
UCEC	Heregulin →	-0.126	-2.000	.023	.032	3	1
UCEC	Ku80 →	+0.233	+3.009	.029	.019	3	1
UCEC	p62 Lck ligand →	+0.356	+2.700	.015	.006	3	1
UCEC	Rab11 →	-0.186	-3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by COX11 expression — UCEC

Explore this box plot interactively →