COX10

Across TCGA patient cohorts, COX10 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX10-associated genes across cancer lineages are eEF2, ERK2, and GSK-3a-b_pS21_S9. Each is linked with COX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX10-to-partner and partner-to-COX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by COX10-low versus COX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX10→partner) and Y-score (partner→COX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.337	+2.321	.014	.033	3	2
UCEC	ERK2 →	+0.194	+2.000	.008	.030	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.362	+1.884	.027	.030	3	2
UCEC	ACC1 →	+0.409	+2.013	.003	.016	3	2
UCEC	PCNA →	+0.185	+1.678	.025	.023	3	2
UCEC	Cyclin-E1 →	+0.329	+2.321	.049	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by COX10 expression — UCEC

Explore this box plot interactively →