COX10

Across TCGA cell cohorts, COX10 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COX10-associated genes across cancer lineages are C5orf52, GCAT, and ANKRD54. Each is linked with COX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both COX10-to-partner and partner-to-COX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by COX10-low versus COX10-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX10→partner) and Y-score (partner→COX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C5orf52 →	+0.041	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.543	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.552	+3.451	.001	.002	3	1
LARGE_INTESTINE	IFT27 →	+0.784	+3.451	.006	.002	3	1
LARGE_INTESTINE	SIGLEC8 →	+0.006	+2.538	.006	.005	3	1
LARGE_INTESTINE	HOXA1 →	-1.055	-3.278	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

C5orf52 by COX10 expression — SKIN

Explore this box plot interactively →