COX10-AS1

Across TCGA pan-cancer cohorts, COX10-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of COX10-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where COX10-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types COX10-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where COX10-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX10-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.547	<.001	11	view →
KICH	Female	II,III,IV	−0.649	<.001	5	view →
COAD	Male	All	+0.341	.002	5	view →
LUSC	Male	All	+0.377	<.001	4	view →
LUAD	All	All	+0.280	<.001	4	view →
KIRP	All	All	+0.274	.006	4	view →
CHOL	Male	All	+1.175	<.001	3	view →
BLCA	All	All	+0.413	.010	3	view →
KIRC	All	All	+0.135	.008	3	view →
HNSC	All	All	+0.234	.016	2	view →
READ	Female	All	+0.359	.015	1	view →
STAD	All	II,III,IV	+0.294	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

COX10-AS1–THCA

Open the THCA breakdown →