CORT

Across TCGA patient cohorts, CORT mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORT-associated genes across cancer lineages are RN7SKP99, MTND6P20, and IGKV1OR9-2. Each is linked with CORT in more than 1 cancer types. Because this analysis shows association rather than direction, both CORT-to-partner and partner-to-CORT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP99 grouped by CORT-low versus CORT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORT→partner) and Y-score (partner→CORT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP99 →	+0.119	+7.816	<.001	.008	3	1
SKCM	MTND6P20 →	+0.089	+7.816	<.001	.008	3	1
UCEC	IGKV1OR9-2 →	+0.884	+4.279	<.001	.008	3	1
UCEC	IGHD6-25 →	+2.565	+5.184	<.001	.001	3	1
UCEC	RPS27P20 →	+0.306	+4.448	.007	.006	3	1
UCEC	RNU6-781P →	+0.936	+4.633	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

RN7SKP99 by CORT expression — SKCM

Explore this box plot interactively →