CORT

Across TCGA cell cohorts, CORT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CORT-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Negative regulation of mRNA processing, and Microtubule nucleation. Each is linked with CORT in more than 12 cancer types. Because this analysis shows association rather than direction, both CORT-to-partner and partner-to-CORT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by CORT-low versus CORT-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CORT→partner) and Y-score (partner→CORT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of mRNA splicing, via spliceosome →	+0.103	+0.352	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of mRNA processing →	+0.100	+0.360	<.001	<.001	3	13
LARGE_INTESTINE	Microtubule nucleation →	+0.102	+0.417	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.118	+0.224	.003	.005	3	12
URINARY_TRACT	Regulation of autophagy of mitochondrion →	+0.095	+0.470	.001	.003	3	12
SOFT_TISSUE	Negative regulation of RNA splicing →	+0.094	+0.426	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,272 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by CORT expression — LARGE_INTESTINE

Explore this box plot interactively →