CORO7-PAM16

Across TCGA pan-cancer cohorts, CORO7-PAM16 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CORO7-PAM16 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CORO7-PAM16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CORO7-PAM16 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUAD show a favorable association.

ACC, LIHC, and KIRC are the cancer types where CORO7-PAM16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.168	0.646	.001	34	view →
LIHC	OS	Tertile	All	0.651	0.823	<.001	27	view →
KIRC	DFS	Quartile	II,III,IV	0.621	0.804	.011	25	view →
SCLC	OS	Quartile	All	0.799	0.426	.001	23	view →
LUAD	OS	Median	II,III,IV	0.860	0.653	<.001	21	view →
LUSC	DFS	Quartile	III,IV	0.877	0.506	.017	16	view →
CHOL	DFS	Quartile	II,III,IV	0.759	0.317	.007	15	view →
LGG	OS	Median	All	0.931	0.858	<.001	14	view →
ESCA	OS	Tertile	All	0.436	0.663	.013	14	view →
BLCA	OS	Tertile	IV	0.233	0.755	.006	11	view →
KIRP	DFS	Quartile	III,IV	0.040	0.927	.014	7	view →
SKCM	OS	Median	All	0.294	0.373	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CORO7-PAM16–ACC (DFS)

Open the ACC breakdown →