CORO2B

Across TCGA patient cohorts, CORO2B mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO2B-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC_pS79, and p27_pT198. Each is linked with CORO2B in more than 2 cancer types. Because this analysis shows association rather than direction, both CORO2B-to-partner and partner-to-CORO2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CORO2B-low versus CORO2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO2B→partner) and Y-score (partner→CORO2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.474	+2.135	.023	.010	3	3
UCEC	ACC_pS79 →	+0.287	+1.362	.019	.037	3	2
UCEC	p27_pT198 →	+0.077	+1.362	.042	.037	3	2
UCEC	VEGFR2 →	+0.246	+1.375	.019	.024	3	2
UCEC	ATM →	-0.625	-3.571	<.001	.002	3	2
UCEC	C-Raf →	+0.169	+2.000	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by CORO2B expression — UCEC

Explore this box plot interactively →