CORO2B

Across TCGA pan-cancer cohorts, CORO2B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CORO2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CORO2B RNA is repressed in tumor relative to normal tissue. In most cancer types CORO2B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where CORO2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CORO2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.517	<.001	12	view →
THCA	Male	III,IV	−2.612	<.001	11	view →
COAD	Female	II,III,IV	−1.334	<.001	10	view →
LUAD	Female	III,IV	−1.936	<.001	9	view →
KICH	Female	II,III,IV	−3.082	<.001	8	view →
LUSC	Female	II,III,IV	−2.414	<.001	8	view →
KIRP	Male	III,IV	−1.991	<.001	8	view →
UCEC	All	II,III,IV	−3.637	<.001	6	view →
BRCA	All	II,III,IV	−1.882	<.001	6	view →
BLCA	Male	All	−1.515	<.001	6	view →
READ	All	III,IV	−1.479	.009	5	view →
HNSC	Male	IV	−0.840	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CORO2B–KIRC

Open the KIRC breakdown →