CORO2A

Across TCGA patient cohorts, CORO2A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO2A-associated genes across cancer lineages are ASNS, MEK1, and PDCD4. Each is linked with CORO2A in more than 2 cancer types. Because this analysis shows association rather than direction, both CORO2A-to-partner and partner-to-CORO2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CORO2A-low versus CORO2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO2A→partner) and Y-score (partner→CORO2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.373	+3.169	.008	.018	3	3
UCEC	MEK1 →	+0.365	+2.807	.011	.003	3	2
UCEC	PDCD4 →	-0.595	-2.502	.001	.002	3	2
UCEC	ATM →	-0.464	-1.584	.009	.036	3	2
UCEC	eEF2 →	+0.403	+2.459	.004	.018	3	1
UCEC	EGFR_pY1068 →	-0.328	-3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ASNS by CORO2A expression — UCEC

Explore this box plot interactively →