CORO2A

Across TCGA pan-cancer cohorts, CORO2A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CORO2A data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CORO2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CORO2A expression acts as an unfavorable survival marker, although some lineages such as ACC and BRCA show a favorable association.

KIRP, ACC, and HNSC are the cancer types where CORO2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.709	0.919	<.001	93	view →
ACC	OS	Median	II,III,IV	0.882	0.633	.001	85	view →
HNSC	OS	Median	All	0.471	0.717	<.001	38	view →
BRCA	OS	Median	IV	0.839	0.355	.002	36	view →
UVM	DFS	Tertile	All	0.361	0.720	.014	32	view →
PAAD	OS	Quartile	All	0.242	0.691	.001	27	view →
UCS	DFS	Tertile	IV	0.528	0.996	.036	24	view →
SCLC	DFS	Tertile	All	0.462	0.133	.008	20	view →
MESO	OS	Tertile	All	0.280	0.488	.005	19	view →
LGG	OS	Quartile	All	0.724	0.888	<.001	17	view →
LUSC	OS	Tertile	II,III,IV	0.803	0.648	.010	12	view →
THCA	OS	Quartile	All	1.000	0.809	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CORO2A–KIRP (DFS)

Open the KIRP breakdown →