Across TCGA pan-cancer cohorts, CORO1CP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CORO1CP1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where CORO1CP1 RNA is repressed in tumor relative to normal tissue. In most cancer types CORO1CP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA, KIRC, and LIHC are the cancer types where CORO1CP1 tumor–normal differential expression is most reproducible.