CORO1A

Across TCGA pan-cancer cohorts, CORO1A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CORO1A data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CORO1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CORO1A expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where CORO1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.855	1.000	.016	96	view →
LUAD	DFS	Median	All	0.776	0.514	.002	21	view →
PDAC	OS	Tertile	III,IV	0.260	1.000	.001	20	view →
HNSC	OS	Tertile	All	1.000	0.375	.040	12	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.802	0.488	.023	2	view →
LSCC	DFS	Quartile	All	0.815	0.369	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CORO1A–COAD (DFS)

Open the COAD breakdown →