CORO1A

Across TCGA pan-cancer cohorts, CORO1A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CORO1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CORO1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CORO1A is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where CORO1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CORO1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.595	<.001	12	view →
KIRP	Male	All	+1.545	<.001	9	view →
STAD	All	II,III,IV	+1.419	.003	6	view →
LUSC	All	II,III,IV	−1.051	<.001	6	view →
BRCA	All	All	+0.522	<.001	4	view →
THCA	All	IV	+2.230	<.001	3	view →
LIHC	Female	II,III,IV	+0.997	.011	3	view →
HNSC	All	All	+0.457	.031	2	view →
CHOL	Female	All	+2.243	.031	1	view →
ESCA	All	All	+1.477	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CORO1A–KIRC

Open the KIRC breakdown →