CORO1A

Across TCGA patient cohorts, CORO1A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORO1A-associated genes across cancer lineages are ERK2, PCNA, and VEGFR2. Each is linked with CORO1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CORO1A-to-partner and partner-to-CORO1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CORO1A-low versus CORO1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORO1A→partner) and Y-score (partner→CORO1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.224	+2.321	.004	.006	3	2
UCEC	PCNA →	+0.232	+2.321	.009	.006	3	2
UCEC	VEGFR2 →	+0.348	+1.820	.004	.016	3	2
UCEC	Cyclin-B1 →	+0.517	+2.321	.025	.006	3	2
UCEC	14-3-3_beta →	-0.095	-3.143	.021	.018	3	1
UCEC	eIF4E →	+0.213	+3.183	.014	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by CORO1A expression — UCEC

Explore this box plot interactively →