COQ8B

Across TCGA patient cohorts, COQ8B mutation is significantly associated with the RNA expression of many other genes, with 502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ8B-associated genes across cancer lineages are OR7E87P, RNU1-49P, and COX10. Each is linked with COQ8B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ8B-to-partner and partner-to-COQ8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E87P grouped by COQ8B-low versus COQ8B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ8B→partner) and Y-score (partner→COQ8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E87P →	+0.090	+3.949	<.001	<.001	3	2
SKCM	RNU1-49P →	+0.366	+4.671	<.001	.004	3	2
UCEC	COX10 →	+0.421	+3.332	.003	.005	3	2
UCEC	ME2 →	+0.574	+2.332	.001	.003	3	2
UCEC	LINC02446 →	+0.659	+2.831	.006	.001	3	2
UCEC	ACO1 →	+0.624	+3.601	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 502 associations by consensus.

OR7E87P by COQ8B expression — SKCM

Explore this box plot interactively →