COQ6

Across TCGA pan-cancer cohorts, COQ6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COQ6 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COQ6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COQ6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where COQ6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.293	0.726	.005	32	view →
UCEC	DFS	Tertile	II,III,IV	0.379	0.914	.004	12	view →
PDAC	DFS	Median	All	0.427	0.221	.021	5	view →
CCRCC	DFS	Tertile	II,III,IV	0.306	0.740	.049	2	view →
HNSC	DFS	Quartile	III,IV	0.794	0.526	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COQ6–LUAD (DFS)

Open the LUAD breakdown →