COQ6

Across TCGA cell cohorts, COQ6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,746 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COQ6-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Telomere organization, and mRNA 5'-splice site recognition. Each is linked with COQ6 in more than 12 cancer types. Because this analysis shows association rather than direction, both COQ6-to-partner and partner-to-COQ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by COQ6-low versus COQ6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ6→partner) and Y-score (partner→COQ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.132	+1.125	<.001	<.001	3	13
PANCREAS	Telomere organization →	+0.055	+0.540	.008	.003	3	12
LUNG_NSCLC_LUSC	mRNA 5'-splice site recognition →	+0.098	+0.669	<.001	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.057	+0.755	<.001	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.123	+1.125	<.001	<.001	3	12
BONE	Vacuole organization →	+0.049	+0.551	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,746 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by COQ6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →