COQ4

Across TCGA pan-cancer cohorts, COQ4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COQ4 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COQ4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COQ4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where COQ4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.968	0.539	.001	30	view →
CCRCC	OS	Quartile	All	1.000	0.287	.007	17	view →
LSCC	OS	Median	II,III,IV	0.933	0.604	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COQ4–PDAC (DFS)

Open the PDAC breakdown →