COQ4

Across TCGA pan-cancer cohorts, COQ4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of COQ4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where COQ4 RNA is repressed in tumor relative to normal tissue. In most cancer types COQ4 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and STAD are the cancer types where COQ4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COQ4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.884	<.001	10	view →
THCA	Male	III,IV	−0.554	<.001	8	view →
STAD	All	II,III,IV	+0.474	.002	6	view →
BRCA	All	III,IV	+0.414	.012	6	view →
LIHC	Female	All	+0.426	<.001	5	view →
CHOL	All	All	+1.262	<.001	4	view →
PRAD	All	All	+0.244	.001	2	view →
KIRC	Male	All	−0.201	.013	2	view →
BLCA	All	III,IV	+0.617	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

COQ4–KICH

Open the KICH breakdown →