COQ4

Across TCGA patient cohorts, COQ4 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ4-associated genes across cancer lineages are p62 Lck ligand, Notch1, and TIGAR. Each is linked with COQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ4-to-partner and partner-to-COQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by COQ4-low versus COQ4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ4→partner) and Y-score (partner→COQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.388	+3.169	.030	.020	3	1
UCEC	Notch1 →	+0.201	+3.009	.009	.019	2	1
UCEC	TIGAR →	+0.182	+3.196	.030	.010	1	1
UCEC	CDK1 →	-0.180	-3.169	.030	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p62 Lck ligand by COQ4 expression — UCEC

Explore this box plot interactively →